OP, do you have a code reader or a way to clear your codes? If so, clear the codes and swap your 4 & 5 coil packs with the ones in 1 & 2. Start the car again and see if the misfire shows up on 1 & 2 now. If it does, you have two bad coilpacks.
If your codes are still faulting on cylinder 4 &5, then I would look at other things.
I had 3 coil packs go bad all at the same time. It is not uncommon for the coilpacks to fail and I would personally start there.
MODS: 03 M3, 6MT, PSS9, AFE Intake, El Diablo Exhaust, Turner Motorsports Rear Adjustable Camber Arms, PowerFlex bushings, 18'x9' square setup & one driver that grins ear to ear everytime he is driving it